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Patients with a history of suicidal ideation or attempts should be carefully evaluated before initiating treatment with Semaglutide / Cyanocobalamin Injection, as post-marketing reports have described occurrences of suicidal thoughts and behaviors in patients treated with GLP-1 receptor agonists

Moreover, some antidepressants seem to exert noteworthy antimicrobial effects, having been proposed that their effectiveness can be, at least partially, consequence of the effects on gut microbiota [261]

This might be responsible for the low IGF-I levels seen in association with states of insulin resistance, as the metabolic syndrome [301]

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Therapies that enhance antioxidant defences are crucial to counteract this injury [47,48]